© 2000 by European Society of Cardiology
Copyright © 2000, European Society of Cardiology
The ‘Second Factor’ of tachycardia-induced atrial remodeling
Dept. of Cardiology, Thoraxcenter, University Hospital Groningen, P.O. Box 30.001, 9700 RB Groningen, Netherlands
* Corresponding author. Tel.: +31-50-361-2355; fax: +31-50-361-4391
Received 6 March 2000; accepted 13 March 2000
| The first 10% of the full text of this article appears below. |
See article by Van der Velden et al. [6] (pages 476–486) in this issue.
During recent years, atrial fibrillation (AF) research has received increasing attention. One of the explanations for this may be the ageing of the population with an increase in the prevalence of AF. Another important reason surely is the discovery of AF-induced atrial electrical remodeling as originally described by Wijffels et al. [1] in their masterpiece article ‘AF begets AF’. In this article the authors described the effects of automatic repetitive re-induction of AF by a ‘fibrillation-pacemaker’ on atrial electrophysiology in previously healthy, chronically instrumented goats. At the start of the protocol the induced episodes of AF typically lasted just a few seconds after which a new episode had to be induced automatically by the pacemaker. However, with an increased duration of the stimulation protocol, the induced episodes prolonged until eventually AF did not convert spontaneously
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1 Conduction slowing and stabilisation of AF |
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2 Structural remodeling and the vulnerability for AF |
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3 Conclusion |
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