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Cardiovascular Research 2000 46(2):211-213; doi:10.1016/S0008-6363(00)00045-6
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

A Whisper on the wind spawns a storm

Karl T. Weber*

Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis College of Medicine, Memphis, TN USA

* Corresponding author. Tel.: +901-448-5759; fax: +901-448-8084 KTWeber@utmem.edu

Received 11 February 2000; accepted 14 February 2000

The first 10% of the full text of this article appears below.

The heart, like many other organs, is composed of parenchyma surrounded by stroma. In this case, highly differentiated and very specialized cardiac myocytes are connected to and tethered within a three dimensional scaffolding of structural protein. Cardiac myocytes number one-third of cells found in the heart. Noncardiomyocytes, such as fibroblasts, endothelial and vascular smooth muscle cells, account for the majority of the remaining two-thirds. Interstitial fibroblasts are responsible for normal synthesis and degradation of this extracellular network, an albeit slow yet nonetheless ongoing process [1]. Fibroblasts are undifferentiated and pluripotent with a diverse portfolio of phenotypic expressions and functions. Myofibroblasts are an example of specialized fibroblast-like cells that appear at sites of tissue repair to carry out fibrogenesis and other functions [2].

Type I collagen is the dominant fibrillar collagen of the heart’s . . . [Full Text of this Article]


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