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Cardiovascular Research 2000 46(1):24-27; doi:10.1016/S0008-6363(00)00020-1
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Mitochondria — potential role in cell life and death

Elinor J. Griffiths*

Bristol Heart Institute, Department of Cardiac Surgery, Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK

* Tel.: +44-117-928-3586; fax: +44-117-928-3581 elinor.griffiths@bristol.ac.uk

Received 25 January 2000; accepted 25 January 2000

KEYWORDS FCCP, carbonylcyanide p-trifluoromethoxyphenylhydrazone; JC-1, 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine iodide; TMRE, tetramethylrhodamine ethyl ester; TMRM, tetramethylrhodamine methyl ester; {Delta}{Psi}m, mitochondrial membrane potential

The first 150 words of the full text of this article appear below.

See article by Mathur et al. [10] (pages 126–138) in this issue.


   1 Mitochondria — potential role in cell life and death
 
The 1990s saw a huge resurgence of interest in the role of mitochondria within cells, recognition that, as well as their traditional role as ‘powerhouses’ of the cell in generating ATP, mitochondria play an important role in other aspects of normal cell functioning, for example in cell calcium signalling. But possibly the greatest interest has been in the emerging role of mitochondria as regulators of the cell life–death transition, in both necrotic and apoptotic forms of cell death (for recent reviews see [1–3]). Changes in mitochondrial membrane potential ({Delta}{Psi}m) are integral to the cell life–death transition [4], although whether as a primary cause or secondary event is as yet not known. Thus, measurements of {Delta}{Psi}m can greatly facilitate our understanding of this process.

In physiological cell functioning, maintenance of {Delta}{Psi}m is essential for ATP synthesis, as has . . . [Full Text of this Article]

1.1 Detection of {Delta}{Psi}m in living cardiomyocytes
1.2 Measurements of {Delta}{Psi}m in physiological and pathological myocyte function

   2 Conclusion
 

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