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Cardiovascular Research 2000 46(1):14-16; doi:10.1016/S0008-6363(00)00033-X
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

What we can learn from individual resuscitated patients

Arthur A.M. Wildea,* and Marieke W. Veldkampb

aAcademic Medical Center, Experimental and Molecular Cardiology Group, Amsterdam University, Amsterdam, The Netherlands
bInteruniversity Cardiology Institute The Netherlands (ICIN), Amsterdam, The Netherlands

* Corresponding author. Tel.: +31-20-566-3265; fax: +31-20-697-5458 a.a.wilde@amc.uva.nl

Received 31 January 2000; accepted 3 February 2000

The first 10% of the full text of this article appears below.

See article by Deschênes et al. [3] (pages 55–65) in this issue.

Successfully resuscitated patients without structural cardiac abnormalities (despite extensive investigations) are diagnosed as suffering from "primary electrical disease". Within this group of patients the Long QT syndrome (LQTS) and Brugada syndrome are electrocardiographically discernible, although the abnormalities may be difficult to appreciate. Both syndromes share an autosomal dominant transmission based on mutations in ion channel genes and a high incidence of sudden cardiac death [1]. The number of disease-related mutations in various genes is growing rapidly, challenging the scientific community to get insight into channel (dys-)function and its relation to these diseases. In HERG for example, different mutations, ultimately leading to functionally less repolarizing currents, appear to affect channel function in different ways [2]. Such . . . [Full Text of this Article]


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