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Cardiovascular Research 2000 45(3):525-527; doi:10.1016/S0008-6363(99)00404-6
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Apoptosis

Marcel Borgersa,b,*, Liisa-Maria Voipio-Pulkkic and Seigo Izumod

aJanssen Research Foundation, Beerse, Belgium
bCARIM, Maastricht University, Maastricht, The Netherlands
cDepartment of Medicine, University of Turku, Turku, Finland
dBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA

* Corresponding author

Received 11 November 1999; accepted 11 November 1999

The first 10% of the full text of this article appears below.

This spotlight issue on apoptosis in the cardiovascular system appears at a point in time at which enough solid evidence has emerged to convince the most critical investigator of the prevalence of the phenomenon in most of the important cardiac and vascular diseases. The aim of this issue is, first, to give the cardiovascular investigator an introduction and overview with reference to the vast literature dealing with myocardial and vascular apoptosis and, second, to include a number of highly qualified original papers on this topic.

By way of accomplishing these two aims, the issue is organised into the following six sections:

1. Detection and Basic Mechanisms of Apoptosis.

The section opens with a paper by Saraste and Pulkki [1] that reviews the current knowledge on the molecular mechanisms of apoptosis as they relate to morphologic hallmarks and their implications for the detection of apoptosis in cardiac tissue. Of special . . . [Full Text of this Article]


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