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Cardiovascular Research 2000 45(2):270-272; doi:10.1016/S0008-6363(99)00392-2
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

About the role of shear stress in atherogenesis

Stephan J.L Bakker and Reinold O.B Gans*

Department of Internal Medicine, University Hospital Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands

* Corresponding author. Tel.: +31-50-361-2587; fax: +31-50-361-9069 r.o.b.gans@int.azg.nl

Received 29 October 1999; accepted 29 October 1999

The first 150 words of the full text of this article appear below.

See article by Gosnach et al. [22] (pages 486–492) in this issue.

As blood flows through a vessel, it exerts a physical force on the vessel wall. This force can be resolved into two principal vectors [1]. One, shear stress, is parallel to the vessel wall. It represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall. The other, tensile stress, is perpendicular to the vessel wall. It represents the dilating force of blood pressure on the vessel wall. The whole vessel wall, including the endothelium, smooth muscle cells and the extracellular matrix, is exposed to it. In contrast, only the inner surface of the vessel wall, the endothelial cells, are exposed to the frictional force of shear stress. There is some slow transmural flow around smooth muscle cells in arterial walls, but this force is considered insignificant when compared with . . . [Full Text of this Article]


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