© 2000 by European Society of Cardiology
Copyright © 2000, European Society of Cardiology
Mechano-electrical feedback
VA Medical Center and Georgetown University School of Medicine, 50 Irving St., NW, Washington, DC 20422, USA
* Tel.: +1-202-745-8398; fax: +1-202-745-8184 mfranz@washington.va.gov
Received 26 October 1999; accepted 26 October 1999
| The first 150 words of the full text of this article appear below. |
See article by Nanthakumar et al. [6] (pages 303–309) in this issue.
 |
1 Introduction |
|---|
During the last two decades, there has been growing interest in the effect that mechanical heart disorders have on the heart's electrophysiological properties. It has been shown in numerous animal experiments that myocardial stretch produced by volume or pressure overload or direct distension of a muscle strip leads to significant electrophysiological changes [1,2]. This interaction, which has been termed mechano-electrical feedback (MEF), is a concept that undoubtedly has evolved into an accepted mechanism today. MEF describes electrophysiological changes caused by changes in myocardial segment length. These changes most notably include: (1) a shortening of the action potential duration (APD), (2) a decrease in the resting diastolic potential, (3) a decrease in the maximum systolic action potential amplitude, (4) development of early afterdepolarizations, (5) ectopic beats originating from afterdepolarization in myocardium sustaining the greatest stretch (reaching threshold for
1.1 Minimal changes in repolarization
|
2 Previous observations |
|---|
2.1 Clinical relevance of MEF
2.2 How does MEF relate to arrhythmogenesis?
2.3 The ionic mechanism
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Kubota, M. Kawasaki, N. Takasugi, U. Takeyama, Y. Ishihara, M. Okubo, T. Yamaki, S. Ojio, T. Aoyama, M. Arai, et al. Evaluation of Left Atrial Degeneration for the Prediction of Atrial Fibrillation: Usefulness of Integrated Backscatter Transesophageal Echocardiography J. Am. Coll. Cardiol. Img., September 1, 2009; 2(9): 1039 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Frazier, K. S. Stone, D. Moser, R. Schlanger, C. Carle, L. Pender, J. Widener, and H. Brom Hemodynamic Changes During Discontinuation of Mechanical Ventilation in Medical Intensive Care Unit Patients Am. J. Crit. Care., November 1, 2006; 15(6): 580 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Chen, D. J. Penny, G. Greve, and M. J. Lab Stretch-induced regional mechanoelectric dispersion and arrhythmia in the right ventricle of anesthetized lambs Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1008 - H1014. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P R James, S M C Hardman, and P Taggart Physiological changes in ventricular filling alter cardiac electrophysiology in patients with abnormal ventricular function Heart, August 1, 2002; 88(2): 149 - 152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Allessie, P. A. Boyden, A. J. Camm, A. G. Kleber, M. J. Lab, M. J. Legato, M. R. Rosen, P. J. Schwartz, P. M. Spooner, D. R. Van Wagoner, et al. Pathophysiology and Prevention of Atrial Fibrillation Circulation, February 6, 2001; 103(5): 769 - 777. [Full Text] [PDF]
|
|