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Cardiovascular Research 2000 45(1):97-99; doi:10.1016/S0008-6363(99)00293-X
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Commentary on "Effects of ischaemia and reperfusion on calcium exchange and mechanical function in isolated rabbit myocardium"

P.D.V Bourdillon and P.A Poole-Wilson*

National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK

* Corresponding author. Tel.: +44-1207-351-8179; fax: +44-1207-351-8113 p.poole-wilson@ic.ac.uk

KEYWORDS Calcium (cellular); Ischemia; Reperfusion; Ventricular function

The first 10% of the full text of this article appears below.


   1 Introduction
 
Rereading and commenting upon an article written 18 years ago is almost to intrude on the prerogatives of history. Wallowing in nostalgia may be a satisfying activity but is not a plausible method for identifying, posing or answering scientific questions. I reread this paper with trepidation but was relieved, perhaps the correct sentiment, to find that it still addressed an important issue. More surprising was the realisation of how limited has been the progress made over the last two decades.

In 1974, as a young research worker, I was fortunate to work in the laboratories of Glen Langer in Los Angeles, supported by the British Heart Foundation. Previously in London I had been investigating the net change in potassium homeostasis in cardiac and skeletal muscle, in vivo, in response to alterations of acid–base balance. Glen Langer had developed a technique which allowed the measurement not just . . . [Full Text of this Article]


   2 Methods
 

   3 Rationale
 

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