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Cardiovascular Research 2000 45(1):55-56; doi:10.1016/S0008-6363(99)00308-9
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification

Terry Campbell*

Professor of Medicine, Head of the Department of Medicine, St Vincent's Hospital, Victoria St, Darlinghurst 2010, NSW, Australia

* Tel.: +61-2-9361-2352; fax: +61-2-9361-2794 tcampbell@stvincents.com.au

KEYWORDS Antiarrhythmic agents; Conduction (block); Membrane potential; Ventricular arrhythmias

The first 10% of the full text of this article appears below.

This paper consolidated the work I had been carrying out for the preceding 3 years as a graduate student in the laboratory of Dr. E.M. Vaughan Williams in the Department of Pharmacology at Oxford and it formed the basis of my D.Phil thesis.

I had gone to Oxford from Sydney, Australia on a Nuffield Scholarship, (the same scholarship that had brought Dr. Bramah Singh to the same laboratory from New Zealand approximately a decade earlier). We had both gone to study with Dr. Vaughan Williams, recognised then and now as one as the pioneering figures in the study of antiarrhythmic drug mechanisms.

I had arrived at the beginning of 1980, fresh from Clinical . . . [Full Text of this Article]


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