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Cardiovascular Research 2000 45(1):215-219; doi:10.1016/S0008-6363(99)00331-4
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

The elusive coypu: the importance of collateral flow and the search for an alternative to the dog

David J Hearse*

Cardiovascular Research, Rayne Institute, St Thomas’ Hospital, London SE1 7EH, UK

* Tel.: +44-171-922-8133; fax: +44-171-928-0658

KEYWORDS Blood flow; Collateral circulation; Coronary circulation; Coronary disease; Infarction; Ischemia

The first 150 words of the full text of this article appear below.


   1 Introduction
 
There are several ‘villains’ in this story: (i) researchers who convinced themselves that myocytes could stay alive without blood; (ii) authors who discarded (or journal editors who refused to publish) negative studies; (iii) dogs that had too much and too variable a collateral flow; (iv) legislation and animal suppliers that made the use of canine preparations (and an intriguing alternative, see Fig. 1) impossible or prohibitively expensive; and (v) a UK government plot to exterminate the coypu (nutria).


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  		Fig. 1 Myocastor coypus molina (known as the coypu or nutria). A giant rat-like beast about 60 cm long and weighting up to 9 kg. Photo: courtesy of Michael Haramis of the Maryland Department of Natural Resources.

 

   2 Infarct size reduction? no problem!
 
For anyone interested in myocardial injury and protection, the 1970s and 1980s were both confusing and exciting. Almost every copy of every journal contained a new paper in which yet another drug reduced infarct size in . . . [Full Text of this Article]


   3 It's negative, we won’t publish it.... unless it's a clinical trial!
 

   4 Understand your model and its pathology before you use it!
 

   5 Collaterals — the key to the problem
 

   6 Problem solved? The challenge of the $1000 dog
 

   7 Defining species difference in collateral flow
 

   8 So what about the coypu?
 

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