© 2000 by European Society of Cardiology
Copyright © 2000, European Society of Cardiology
A historic overview of the paper
An excitatory nociceptive cardiac reflex elicited by bradykinin and potentiated by prostaglandins and myocardial ischaemia (1976)
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KEYWORDS Autonomic nervous system; Ischemia; Vasoactive agents; Vasoconstriction/dilation
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The work described in this paper has a long and complex history. Its origin can be traced back to 1964 when, after receiving my M.D. degree, I was offered by Dr. John Vane (whom I had met in Poland in 1963) a postdoctoral fellowship in his laboratory in the Deptartment of Pharmacology, Royal College of Surgeons of England in London. My work there made use of the original blood-bathed organ (BBO) bioassay technique of Vane [1] to study the release