© 2000 by European Society of Cardiology
Copyright © 2000, European Society of Cardiology
Improved functional recovery by ischaemic preconditioning is not mediated by adenosine in the globally ischaemic isolated rat heart
Department of Cardiology, Denmark Hill Campus, Bessemer Road, London SE5 9PJ, UK
* Tel.: +44-20-7346-4025; fax: +44-20-7346-3685 alison.cave@kcl.ac.uk
KEYWORDS Endothelial factors; Endothelial function; Nitric oxide; Shock; Veins
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The experiments described in this paper were designed and performed between 1991 and 1992 when I was in the final year of my Ph.D studentship. I was introduced to preconditioning at my first American Heart Association meeting in 1989 and was fascinated that evolution had devised an endogenous protective mechanism for the heart, which was far more effective than any intervention developed by man. Not surprising really, considering that evolution has been working on stress adaptation for a couple of a million years! Since the aim of my PhD project was to extend the window of preservation for donor hearts prior to transplantation, after the AHA meeting, I began experiments to explore whether ischaemic preconditioning
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