Na+/H+ exchange hyperactivity and myocardial hypertrophy: Are they linked phenomena?

doi:10.1016/S0008-6363(99)00210-2

Cardiovascular Research 1999 44(3):462-467; doi:10.1016/S0008-6363(99)00210-2
© 1999 by European Society of Cardiology

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Na⁺/H⁺ exchange hyperactivity and myocardial hypertrophy

Are they linked phenomena?

Horacio E. Cingolani^*

Centro de Investigaciones Cardiovasculares, La Plata 1900, Argentina

^* Corresponding author. Tel.: +54-221-483-4833; fax: +54-221-425-5861

Received 3 March 1999; accepted 22 April 1999

The first 150 words of the full text of this article appear below.

1 The Na⁺/H⁺ exchanger

Intracellular pH (pH_i) in the majority of living cells is about6.8–7.2, considerably more alkaline than that predictedfor passive distribution of H⁺ across the cell membrane. Forthe average membrane potential and for an extracellular pH of7.4, a pH_i value of 6.4 should be expected if H⁺ were in electrochemicalequilibrium. At such a pH_i, metabolism and a variety of othercellular functions would be impaired. The existence of mechanismsextruding H⁺ (or acid equivalents) can explain the maintenanceof pH_i well above the equilibrium. The Na⁺/H⁺ exchanger (NHE)is one of these mechanisms and plays a central role in the regulationof pH_i as well as in the control of cell volume and of intracellularNa⁺ concentration ([Na⁺]_i). In addition, the exchanger appearsto facilitate the induction of cellular growth and proliferationin response to numerous growth factors. The NHE has been . . . [Full Text of this Article]

   2 NHE activity and hypertension

   3 NHE, cellular growth and angiotensin II (Ang II)

   4 Mechanism of Ang II-induced activation of NHE

   5 The link between myocardial strain and hypertrophy

   6 NHE activity and hypertrophied myocardium

   7 Effect of antihypertensive treatments on NHE activity

   8 Conclusions

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