© 1999 by European Society of Cardiology
Copyright © 1999, European Society of Cardiology
Atrial fibrillation-induced electrical remodeling in humans
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Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands
* Tel.: +043-388-1202-00; fax: +043-388-41-66
Received 2 August 1999; accepted 2 August 1999
| The first 150 words of the full text of this article appear below. |
See article by Bosch et al. [1] (pages 121–131) in this issue.
In the article elsewhere in this issue, "Ionic mechanisms of electrical remodeling in human atrial fibrillation", Ralph Bosch and co-workers [1] describe the changes in atrial action potential characteristics and ion-channel densities in 8 patients with chronic atrial fibrillation (AF). The action potentials of single atrial cells isolated from patients in AF, showed a normal resting membrane potential more negative than –75 mV and amplitudes higher than 115 mV. However, compared to patients in sinus rhythm the repolarization phase was markedly changed. Both, the early rapid repolarization (phase 1), carried by Ito and the plateau of the action potential mainly carried by ICa,L(phase 2), were clearly attenuated or even abolished. As a result, atrial cells in AF patients seemed to repolarize almost exclusively by phase 3 repolarization. The total duration of the action potential was markedly decreased.
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