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Cardiovascular Research 1999 43(4):827-829; doi:10.1016/S0008-6363(99)00190-X
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Another layer of ventricular heterogeneity? {alpha}1 agonists prolong repolarization in Purkinje fibers but not M-Cells

Thomas J Colatsky*

Physiome Sciences, 307 College Road East, Princeton, NJ 08540, USA

* Corresponding author. Tel.: +1-609-987-1199, ext. 226; fax: +1-609-987-9393 tcolatsky@physiome.com

Received 31 May 1999; accepted 31 May 1999

The first 150 words of the full text of this article appear below.

See article by Burashnikov and Antzelevitch ([1], pages 901–908) in this issue.

The heart is a complex organ and grows more so each day. Past research has firmly established the existence of multiple cell types that co-exist within the myocardium, each demonstrating a unique electrophysiological identity, regional localization, and coupling relationship with neighboring cells that specify the pattern of the heart beat. Within each cardiac cell type, the action potential waveform is determined by a delicate interplay among a variety of inward and outward currents flowing through distinct ion channels, pumps and transporters. The activity of each of these cellular components can in turn be modulated by drugs, hormones and neural stimulation, or modified by disease. While we are rapidly gaining an appreciation for the molecular and genetic events underlying this complexity, there remain significant gaps in our knowledge about how these events become integrated at the cell . . . [Full Text of this Article]


   1 Basic mechanisms: alpha-1-receptors and the heart
 

   2 Clinical implications: alpha-1-receptors and arrhythmogenesis
 

   3 Limitations of the study
 

   4 Conclusions
 

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