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Cardiovascular Research 1999 43(2):288-290; doi:10.1016/S0008-6363(99)00121-2
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Measure is treasure

M.J.B. van den Hoff* and A.F.M. Moorman

Department of Anatomy and Embryology, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

* Corresponding author. Tel.: +31-20-5669111; fax: +31-20-6976177 m.j.vandenhoff@amc.uva.nl a.f.moorman@amc.uva.nl

Received 26 February 1999; accepted 24 March 1999

The first 10% of the full text of this article appears below.

See article by Ribadeau-Dumas et al. [1] (pages 426–436) in this issue.

The paper of Ribadeau-Dumas et al. in this issue [1] deals with the interesting, but complex regulation of the SERCA2 gene. This gene encodes the sarcoplasmatic calcium pump, which is a crucial enzyme in the calcium handling of the cardiomyocyte. Insight into the regulation of this gene is therefore of paramount importance. A proper understanding of the regulation of the expression of a gene in adult, developing, experimental or diseased (cardiac) tissue requires precise knowledge of the control at each step from gene to the function of the encoded protein, comprising RNA and protein accumulation (being the product of synthesis and degradation) and biological activity of the studied protein. This list can . . . [Full Text of this Article]


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