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Cardiovascular Research 1999 43(1):23-24; doi:10.1016/S0008-6363(99)00090-5
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

The ACE gene polymorphism: the good, the bad and the ugly

Yigal M Pinto and Wiek H van Gilst*

Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands

* Corresponding author. Tel.: +31-50-363-2810; fax: +31-50-363-2812.

The first 10% of the full text of this article appears below.

See article by Perticone et al. ([3], pages 192–199) in this issue.

After its first entry into the scientific stage [1] the deletion polymorphism of the Angiotensin Converting Enzyme presented cardiovascular researchers with a grateful opportunity to explore genetic mechanisms in cardiovascular disease. However, after a Good start, conflicting results gave the genotype a Bad reputation, and the stage now looks rather Ugly. After having discovered how promiscuously ACE behaves as an enzyme, it became apparent that the genotype was not much more faithful, being associated with an enormous variety of cardiovascular disorders, ranging from an association with myocardial infarction, vascular . . . [Full Text of this Article]


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