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Cardiovascular Research 1999 42(3):571-575; doi:10.1016/S0008-6363(99)00086-3
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Preconditioning and limitation of stunning

one step closer to the protected protein(s)?

Jos M.J. Lamers*

Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine & Health Sciences, Erasmus University, Rotterdam, The Netherlands

* Corresponding author. Tel.: +31-10-408-7335; fax: +31-10-4089472

Received 2 March 1999; accepted 2 March 1999

KEYWORDS Ischaemia; Reperfusion; Stunning; Preconditioning; Contractile apparatus

The first 150 words of the full text of this article appear below.

Brief periods of ischaemia, are known to induce a reversible deficit in myocardial function despite the maintenance of histological and metabolic integrity, a phenomenon initially described by Heyndrickx et al. in 1975, and called stunning several years after [1]. In that first study it was reported that several hours were required for complete recovery of regional contractility following a 5 min occlusion of the left anterior descending coronary artery in conscious dogs and up to 24 h were needed for complete recovery following a 15 min occlusion [1]. Therefore, myocardial stunning is considered to represent reversible injury contrasting the irreversible injury of myocardial infarction. The phenomenon has been described in every species studied so far, does occur in several clinical settings and likely plays an important role in the morbidity of patients with coronary artery disease [2]. Although the principal cause of the reversible contractile dysfunction is . . . [Full Text of this Article]


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