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Cardiovascular Research 1999 42(3):565-566; doi:10.1016/S0008-6363(99)00041-3
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Guidelines to the use of laboratory animals: what about neuromuscular blocking agents?

Stephan C.U Marsch* and Wolfgang Studer

Department of Anaesthesia, University of Basel, 4031 Basel, Switzerland

marsch@ubaclu.unibas.ch

* Corresponding author. Tel.: +61-265-7254 fax: +61-265-7320

Received 29 January 1999; accepted 29 January 1999

The first 10% of the full text of this article appears below.

Cardiovascular Research requires that investigations in animals conform with the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health. These guidelines advocate that neuromuscular blocking drugs must not be used to provide ‘‘surgical restraint’’ in case of inadequate anaesthesia [1]. There is no doubt that performing painful or distressing procedures on an animal that is paralysed yet conscious is cruel and that animals have to be protected accordingly. The questions arises, whether the above mentioned guidelines protect animals sufficiently against less overt dangers associated with the use of neuromuscular blocking drugs, e.g. awareness.

Awareness with explicit memory . . . [Full Text of this Article]


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