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Cardiovascular Research 1999 42(2):267-269; doi:10.1016/S0008-6363(99)00072-3
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

A spotlight on electrophysiological remodeling and the molecular biology of ion channels

Stanley Nattela,*, Dan M. Rodenb and Denis Escandec

aDepartment of Medicine and Research Center, Montreal Heart Institute, Department of Medicine, University of Motreal, and Department of Pharmacology, McGill University, 5000 Bélanger Street East, Montreal, Quebec H1T 1C8, Canada
bDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
cLab. Physiopath. & Pharm. Cellulaire, INSERM CJF 96-01, Hotel Dieu -4e etage, Place Alexis Ricordeau, 44093 Nantes Cedex 1, France

nattel@icm.umontreal.ca

* Corresponding author. Tel.: +1-514-376-3330; fax: +1-514-376-1355

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The present special issue of Cardiovascular Research focuses on two tightly linked and increasingly important areas of cardiovascular electrophysiology. It has become increasingly apparent that the cardiac electrophysiological milieu is highly dynamic. Not only do disease states affect the determinants of cardiac electrical function in profound ways, but we now recognise that cardiac arrhythmias can themselves produce profound changes in the structure and function of the heart, and that these changes can contribute importantly to the initiation and perpetuation of arrhythmias. Disease- and arrhythmia-induced changes in cardiac electrical properties are referred to as electrophysiological remodeling. Our understanding of the mechanisms and significance of these processes has been greatly enhanced by advances in the molecular biology of cardiac ion channels. Knowledge in this field has permitted rapid advances in the understanding of . . . [Full Text of this Article]


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