© 1999 by European Society of Cardiology
Copyright © 1999, European Society of Cardiology
Vascular remodelling of resistance vessels: can we define this?
Department of Pharmacology, University of Aarhus, 8000 Aarhus C, Denmark
* Tel.: +45-8942-1726; fax: +45-8612-8804; e-mail: mm@farm.aau.dk
Received 3 March 1998; accepted 19 September 1998
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1 Introduction |
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As pointed out originally by Folkow [1], many of the haemodynamic features associated with essential hypertension can be accounted for by alterations in the structure of the resistance vessels. In vivo haemodynamic experiments (where forearm blood flow was measured with the vasculature fully relaxed under conditions of reactive hyperaemia) showed that the relaxed peripheral resistance in essential hypertensive patients was increased, that the pressor response to maximal concentrations of agonists was increased, but that the threshold concentration of agonists which caused vascular contraction was not altered. From simple physical reasoning, it was suggested that these findings could be accounted for by a slight change in the structure of the resistance vessels, such that there is a decrease in the lumen diameter and an increase in the wall (or media) thickness to lumen diameter ratio [2–5]. It is, however, only recently that it has become possible to quantify resistance
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2 Resistance vessel structure |
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3 Definitions of resistance vessel remodelling |
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4 Remodelling of resistance vessel structure in hypertension |
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5 How should remodelling be defined? |
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6 Measurement of remodelling |
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7 Conclusion |
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