© 1998 by European Society of Cardiology
Copyright © 1998, European Society of Cardiology
Animal models in the study of myocardial ischaemia and ischaemic syndromes
Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus University Rotterdam, Rotterdam, The Netherlands
* Corresponding author. Experimental Cardiology, Thoraxcenter, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. Tel.: +31-10-408-8029; Fax: +31-10-436-5607; E-mail: verdouw@tch.fgg.eur.nl
Received 29 October 1997; accepted 12 February 1998
KEYWORDS Myocardial ischaemia; Animal models; Ischaemic syndromes
| The first 150 words of the full text of this article appear below. |
 |
1 Introduction |
|---|
Although myocardial ischaemia has been one of the most extensively studied topics in cardiovascular research, its definition is still debated [1]. In the strictest sense ‘ischaemia’ derived from the Greek words, ischõ (to restrain) and haima (blood), means insufficient blood, and if we would adhere to this definition, all animal models which lack blood (e.g. isolated heart models) should by definition be termed ‘ischaemic'. Most investigators prefer to define ischaemia as an imbalance between the amount of oxygen and substrates supplied to the heart and the amount needed to perform normal function [1, 2]. The rationale behind this definition is that the myocardium strongly depends on oxygen to sustain adequate oxidative phosphorylation, the only metabolic process that is capable of providing sufficient high energy phosphates to maintain normal myocardial contraction. When oxygen supply to the heart becomes impaired there will be inadequate production of high energy phosphates with
1.1 Ischaemia versus hypoxia
1.2 Ischaemia versus infarction
|
2 Myocardial ischaemia |
|---|
2.1 Regional ischaemia
2.1.1 Experimental animal
2.1.2 Collateral circulation
2.1.3 Experimental conditions
2.2 In vivo models of coronary arterial thrombosis
2.3 Global ischaemia (in vitro models)
2.4 Isolated cardiac myocytes
|
3 Ischaemic syndromes |
|---|
3.1 Stunning
3.1.1 In vivo models
3.1.2 Isolated perfused hearts
3.1.3 Limitations of functional parameters
3.2 Ischaemic preconditioning
3.2.1 Experimental design
3.3 Hibernation
|
4 Future developments |
|---|
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. J. van Essen, J. C. M. Vernooij, J. A. P. Heesterbeek, D. Anjema, D. Merkus, and D. J. Duncker Does cardiovascular performance of modern fattening pigs obey allometric scaling laws? J Anim Sci, June 1, 2009; 87(6): 1991 - 1997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. de Chantal, J. G. Diodati, J. B. Nasmith, R. Amyot, A. R. LeBlanc, E. Schampaert, and C. Pharand Progressive epicardial coronary blood flow reduction fails to produce ST-segment depression at normal heart rates Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2889 - H2896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Tarnavski, J. R. McMullen, M. Schinke, Q. Nie, S. Kong, and S. Izumo Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies Physiol Genomics, February 13, 2004; 16(3): 349 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Mancuso, D. R. Abendschein, C. M. Jenkins, X. Han, J. E. Saffitz, R. B. Schuessler, and R. W. Gross Cardiac Ischemia Activates Calcium-independent Phospholipase A2{beta}, Precipitating Ventricular Tachyarrhythmias in Transgenic Mice: RESCUE OF THE LETHAL ELECTROPHYSIOLOGIC PHENOTYPE BY MECHANISM-BASED INHIBITION J. Biol. Chem., June 13, 2003; 278(25): 22231 - 22236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Coles Jr., D. C. Sigg, and P. A. Iaizzo Role of kappa -opioid receptor activation in pharmacological preconditioning of swine Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2091 - H2099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Hughes, M. J. Post, M. Simons, and B. H. Annex Translational Physiology: Porcine models of human coronary artery disease: implications for preclinical trials of therapeutic angiogenesis J Appl Physiol, May 1, 2003; 94(5): 1689 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Sigg, J. A. Coles Jr., P. R. Oeltgen, and P. A. Iaizzo Role of delta -opioid receptor agonists on infarct size reduction in swine Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H1953 - H1960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Musa, H. Dobrzynski, Z. Berry, F. Abidi, C.E. Cass, J.D. Young, S.A. Baldwin, and M.R. Boyett Immunocytochemical Demonstration of the Equilibrative Nucleoside Transporter rENT1 in Rat Sinoatrial Node J. Histochem. Cytochem., March 1, 2002; 50(3): 305 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Oshinski, Z. Yang, J. R. Jones, J. F. Mata, and B. A. French Imaging Time After Gd-DTPA Injection Is Critical in Using Delayed Enhancement to Determine Infarct Size Accurately With Magnetic Resonance Imaging Circulation, December 4, 2001; 104(23): 2838 - 2842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Choi, S. S. Lee, S. I. Choi, S. T. Kim, K. H. Lim, C. H. Lim, H.-J. Weinmann, and T.-H. Lim Occlusive Myocardial Infarction: Investigation of Bis-Gadolinium Mesoporphyrins-enhanced T1-weighted MR Imaging in a Cat Model Radiology, August 1, 2001; 220(2): 436 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. I. P. Trines, C. J. Slager, J. Van der Moer, P. D. Verdouw, and R. Krams Efficiency of energy transfer, but not external work, is maximized in stunned myocardium Am J Physiol Heart Circ Physiol, September 1, 2000; 279(3): H1264 - H1273. [Abstract] [Full Text] [PDF]
|
|