© 1998 by European Society of Cardiology
Copyright © 1998, European Society of Cardiology
Alterations of calcium-regulatory proteins in heart failure
Medizinische Klinik III, Universität Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
* Corresponding author. Tel. (+49-761) 270 3591; Fax (+49-761) 270 3788; E-mail: hasenfus@ruf.uni-freiburg.de
Received 5 August 1997; accepted 3 November 1997
KEYWORDS Calcium channel; Ryanodine receptor; Sarcoplasmic reticulum; Calcium pump; Na+-Ca2+-exchanger
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1 Introduction |
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During the last decade there was accumulating evidence that alterations of excitation-contraction (EC) coupling may play a critical role in the pathophysiology of myocardial failure. EC-coupling comprises processes involved in calcium activation of contractile proteins and the subsequent removal of calcium facilitating relaxation (for review see [1]). The initial event is depolarisation of the membrane which opens voltage-gated, dihydropyridine-sensitive sarcolemmal calcium channels (dihydropyridine receptors) allowing an influx of calcium into the myocyte. There is a close proximity between one or a few sarcolemmal calcium channels and one or a few calcium channels of the sarcoplasmic reticulum (ryanodine receptors). This may enable calcium influx through one opening of a single sarcolemmal calcium channel to increase a local pool of calcium sufficiently to open adjacent ryanodine receptors to release calcium. This local, punctate, increase of calcium is termed calcium spark according to its visualization by confocal microscopy [2]. It is
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2 Sarcolemmal L-type calcium channels |
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2.1 L-type calcium channels in animal models of heart failure
2.2 L-type calcium channels in failing human myocardium
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3 Sarcoplasmic reticulum calcium release channels |
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3.1 Ryanodine receptors in failing animal myocardium
3.2 Ryanodine receptors in failing human myocardium
3.3 IP3R in failing myocardium
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4 Sarcoplasmic reticulum calcium storage proteins |
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4.1 Calsequestrin in failing myocardium
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5 Sarcoplasmic reticulum calcium pump and phospholamban |
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5.1 SR-Ca2+-ATPase in failing animal myocardium
5.2 SR-Ca2+-ATPase in failing human myocardium
5.3 Phospholamban in heart failure
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6 Sarcolemmal calcium pump |
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7 Sarcolemmal sodium-calcium exchanger |
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7.1 Na+-Ca2+-exchanger in animal models of failure
7.2 Na+-Ca2+-exchanger in human heart failure
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8 Interpretation of the data available on calcium-regulatory proteins in heart failure |
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8.1 Comparison of different studies
8.2 Functional relevance of altered calcium-regulatory proteins for the pathophysiology of human heart failure
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A. M. Gomez, B. Schwaller, H. Porzig, G. Vassort, E. Niggli, and M. Egger Increased Exchange Current but Normal Ca2+ Transport via Na+-Ca2+ Exchange During Cardiac Hypertrophy After Myocardial Infarction Circ. Res., August 23, 2002; 91(4): 323 - 330. [Abstract] [Full Text] [PDF]
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N. R. Alpert, L. A. Mulieri, and D. Warshaw The failing human heart Cardiovasc Res, April 1, 2002; 54(1): 1 - 10. [Full Text] [PDF]
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M. Doi, M. Yano, S. Kobayashi, M. Kohno, T. Tokuhisa, S. Okuda, M. Suetsugu, Y. Hisamatsu, T. Ohkusa, M. Kohno, et al. Propranolol Prevents the Development of Heart Failure by Restoring FKBP12.6-Mediated Stabilization of Ryanodine Receptor Circulation, March 19, 2002; 105(11): 1374 - 1379. [Abstract] [Full Text] [PDF]
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 E. TAKIMOTO, A. YAO, H. TOKO, H. TAKANO, M. SHIMOYAMA, M. SONODA, K. WAKIMOTO, T. TAKAHASHI, H. AKAZAWA, M. MIZUKAMI, et al. Sodium calcium exchanger plays a key role in alteration of cardiac function in response to pressure overload FASEB J, March 1, 2002; 16(3): 373 - 378. [Abstract] [Full Text] [PDF]
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 M. HOSHIJIMA, M. PASHMFOROUSH, R. KNOLL, and K.R. CHIEN The MLP Family of Cytoskeletal Z Disc Proteins and Dilated Cardiomyopathy: A Stress Pathway Model for Heart Failure Progression Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 399 - 408. [Abstract] [PDF]
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X.-Q. Zhang, J. Song, L. I. Rothblum, M. Lun, X. Wang, F. Ding, J. Dunn, J. Lytton, P. J. McDermott, and J. Y. Cheung Overexpression of Na+/Ca2+ exchanger alters contractility and SR Ca2+ content in adult rat myocytes Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2079 - H2088. [Abstract] [Full Text] [PDF]
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I. Lemire, A. Ducharme, J.-C. Tardif, F. Poulin, L. R. Jones, B. G. Allen, T. E. Hebert, and H. Rindt Cardiac-directed overexpression of wild-type {alpha}1B-adrenergic receptor induces dilated cardiomyopathy Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H931 - H938. [Abstract] [Full Text] [PDF]
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F. Forini, A. Paolicchi, T. Pizzorusso, G. M. Ratto, M. Saviozzi, V. Vanini, and G. Iervasi 3,5,3'-Triiodothyronine deprivation affects phenotype and intracellular [Ca2+]i of human cardiomyocytes in culture Cardiovasc Res, August 1, 2001; 51(2): 322 - 330. [Abstract] [Full Text] [PDF]
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S. V. Anisimov, E. G. Lakatta, and K. R. Boheler Discovering altered genomic expression patterns in heart: transcriptome determination by serial analysis of gene expression Eur J Heart Fail, June 1, 2001; 3(3): 271 - 281. [Abstract] [Full Text] [PDF]
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Z. Su, A. Yao, I. Zubair, K. Sugishita, M. Ritter, F. Li, J. J. Hunter, K. R. Chien, and W. H. Barry Effects of deletion of muscle LIM protein on myocyte function Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2665 - H2673. [Abstract] [Full Text] [PDF]
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M. Shigekawa and T. Iwamoto Cardiac Na+-Ca2+ Exchange : Molecular and Pharmacological Aspects Circ. Res., May 11, 2001; 88(9): 864 - 876. [Abstract] [Full Text] [PDF]
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M. Periasamy Adenoviral-Mediated SERCA Gene Transfer Into Cardiac Myocytes : How Much Is Too Much? Circ. Res., March 2, 2001; 88(4): 373 - 375. [Full Text] [PDF]
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J.-Q. He, M. W Conklin, J. D Foell, M. R Wolff, R. A Haworth, R. Coronado, and T. J Kamp Reduction in density of transverse tubules and L-type Ca2+ channels in canine tachycardia-induced heart failure Cardiovasc Res, February 1, 2001; 49(2): 298 - 307. [Abstract] [Full Text] [PDF]
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C. M.N. Terracciano, K. D. Philipson, and K. T. MacLeod Overexpression of the Na+/Ca2+ exchanger and inhibition of the sarcoplasmic reticulum Ca2+-ATPase in ventricular myocytes from transgenic mice Cardiovasc Res, January 1, 2001; 49(1): 38 - 47. [Abstract] [Full Text] [PDF]
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K. R. Sipido Local Ca2+ Release in Heart Failure : Timing Is Important Circ. Res., November 24, 2000; 87(11): 966 - 968. [Full Text] [PDF]
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C. M.N Terracciano Sarcoplasmic reticulum calcium release function and FK binding proteins in heart failure: another piece of a complex jigsaw Cardiovasc Res, November 1, 2000; 48(2): 191 - 193. [Full Text] [PDF]
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Y. Tsuji, T. Opthof, K. Kamiya, K. Yasui, W. Liu, Z. Lu, and I. Kodama Pacing-induced heart failure causes a reduction of delayed rectifier potassium currents along with decreases in calcium and transient outward currents in rabbit ventricle Cardiovasc Res, November 1, 2000; 48(2): 300 - 309. [Abstract] [Full Text] [PDF]
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I. Sjaastad, O. M. Sejersted, A. Ilebekk, and R. Bjornerheim Echocardiographic criteria for detection of postinfarction congestive heart failure in rats J Appl Physiol, October 1, 2000; 89(4): 1445 - 1454. [Abstract] [Full Text] [PDF]
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W. H. Barry Na+-Ca2+ Exchange in Failing Myocardium : Friend or Foe? Circ. Res., September 29, 2000; 87(7): 529 - 531. [Full Text] [PDF]
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D. M. Bers Calcium Fluxes Involved in Control of Cardiac Myocyte Contraction Circ. Res., August 18, 2000; 87(4): 275 - 281. [Full Text] [PDF]
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 B. Linck, P. Bokník, S. Huke, U. Kirchhefer, J. Knapp, H. Lüss, F. U. Müller, J. Neumann, Z. Tanriseven, U. Vahlensieck, et al. Functional Properties of Transgenic Mouse Hearts Overexpressing Both Calsequestrin and the Na+-Ca2+ Exchanger J. Pharmacol. Exp. Ther., August 1, 2000; 294(2): 648 - 657. [Abstract] [Full Text]
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L.-Q. Zhang, X.-Q. Zhang, Y.-C. Ng, L. I. Rothblum, T. I. Musch, R. L. Moore, and J. Y. Cheung Sprint training normalizes Ca2+ transients and SR function in postinfarction rat myocytes J Appl Physiol, July 1, 2000; 89(1): 38 - 46. [Abstract] [Full Text] [PDF]
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W. Grossman Defining Diastolic Dysfunction Circulation, May 2, 2000; 101(17): 2020 - 2021. [Full Text] [PDF]
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A. A. Grace and A.J. Camm Voltage-gated calcium-channels and antiarrhythmic drug action Cardiovasc Res, January 1, 2000; 45(1): 43 - 51. [Full Text] [PDF]
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U Ravens and D Dobrev Regulation of sarcoplasmic reticulum Ca2+-ATPase and phospholamban in the failing and nonfailing heart Cardiovasc Res, January 1, 2000; 45(1): 245 - 252. [Full Text] [PDF]
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W. H. Barry Molecular Inotropy : A Future Approach to the Treatment of Heart Failure? Circulation, December 7, 1999; 100(23): 2303 - 2304. [Full Text] [PDF]
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 O.-E. Brodde and M. C. Michel Adrenergic and Muscarinic Receptors in the Human Heart Pharmacol. Rev., December 1, 1999; 51(4): 651 - 690. [Abstract] [Full Text] [PDF]
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E. Niggli Ca2+ Sparks in Cardiac Muscle: Is There Life Without Them? Physiology, August 1, 1999; 14(4): 129 - 134. [Abstract] [Full Text] [PDF]
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R. Hullin, F. Asmus, A. Ludwig, J. Hersel, and P. Boekstegers Subunit Expression of the Cardiac L-Type Calcium Channel Is Differentially Regulated in Diastolic Heart Failure of the Cardiac Allograft Circulation, July 13, 1999; 100(2): 155 - 163. [Abstract] [Full Text] [PDF]
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