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Cardiovascular Research 1998 37(1):8-13; doi:10.1016/S0008-6363(97)00230-7
© 1998 by European Society of Cardiology
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Copyright © 1997, European Society of Cardiology

Primary aldosteronism and its variants

Celso E Gomez-Sancheza,b,*

aDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, University of Missouri-Columbia, Columbia, MO 65201, USA
bEndocrine Section, Harry S. Truman Memorial Veterans Hospital, 800 Hospital Drive, Columbia, MO 65201, USA

* Corresponding author. Tel. +1-573-443-2511X6493; Fax +1-573-884-4609; E-mail: intmdceg@showme.missouri.edu

Received 11 April 1997; accepted 13 August 1997

The first 150 words of the full text of this article appear below.

Primary aldosteronism is an adrenal abnormality in which there is an excessive production of aldosterone above that required for electrolyte homeostasis which is not driven by known stimulators of aldosterone secretion, although these may retain some degree of modulatory activity on aldosterone secretion. In the early years following the description of primary aldosteronism, the etiology was ascribed to the autonomous production of aldosterone by an adrenal adenoma for which surgical treatment resulted in the resolution of the hypokalemia and cure or improvement of the hypertension in many cases [1]. At this time the possibility of aldosteronism due to adrenal hyperplasia was not recognized. The traditional clinical picture was characterized by salt-sensitive hypertension associated with hypokalemia and suppression of renin secretion [1]. A major emphasis in the selection of patients for consideration for diagnostic procedures for primary aldosteronism was the presence of spontaneous or easily-induced hypokalemia, resulting in an . . . [Full Text of this Article]


   1 Incidence of primary aldosteronism
 

   2 Screening and diagnosis for primary aldosteronism
 

   3 Plasma aldosterone/renin ratio (PA/PRA)
 

   4 Dynamic tests for primary aldosteronism
 

   5 Sequelae of primary aldosteronism
 

   6 Recommended approach to diagnosis and therapy
 

   7 Types and sub types of primary aldosteronism
 

   8 18-Hydroxycorticosterone levels
 

   9 18-Hydroxycortisol and 18-oxocortisol
 

   10 Pathology and imaging of the adrenals in primary aldosteronism
 

   11 Pathogenesis
 

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