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Cardiovascular Research 1997 36(3):310-322; doi:10.1016/S0008-6363(97)00239-3
© 1997 by European Society of Cardiology
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Copyright © 1997, European Society of Cardiology

Signal transduction revisited: recent developments in angiotensin II signaling in the cardiovascular system

Marc van Bilsen*

Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD Maastricht, Netherlands

* Corresponding author. Tel. +31-43-3881204; Fax +31-43-3671028; E-mail: marc.vanbilsen@fys.unimaas.nl

Received 21 July 1997; accepted 15 September 1997

KEYWORDS Angiotensin II; Signal transduction; Protein kinase C; MAP kinase; Tyrosine kinase; Cytokine

The first 150 words of the full text of this article appear below.


   1 Introduction
 
Two years have passed since the appearance of the focused issue on signal transduction (Cardiovascular Research, volume 30, issue 4, October 1995). In that issue a selection of topics related to cardiovascular signal transduction were highlighted. Since then a wealth of new information has deepened our insight into the factors that govern the activity of the different signal transduction pathways. Moreover, the importance of cross-talk between signal transduction pathways is being recognized and has, at the same time, made us aware of the complexity of the signal transduction network. Finally, new players in the field of cardiovascular signal transduction have emerged, the most striking example being the Stress-Activated Protein Kinases.

The purpose of this review is to summarize these new developments in this area of research. Considering the rate with which the various signal transduction pathways and their interrelationships are being deciphered the task of writing an update that pays . . . [Full Text of this Article]


   2 Mechanical forces and signal transduction
 

   3 Systemic and local angiotensin II
 

   4 Angiotensin II receptors
 

   5 The AT2 receptor
 

   6 Signaling through the AT1 receptor
 
6.1 Involvement of different phospholipase C-isoforms
6.2 G-protein/PLC-β mediated signaling
6.3 The AT1 receptor/PLC-{gamma} connection
6.4 Protein kinase C
6.5 The PKC/MAPK connection
6.6 Signaling through p21 Ras
6.7 The JAK/STAT pathway

   7 Signaling through cytokine receptors
 

   8 Stress-activated protein kinases
 

   9 Conclusions
 

   10 List of abbreviations
 

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