© 1997 by European Society of Cardiology
Copyright © 1997, European Society of Cardiology
Gene transfer and cell transplant: an experimental approach to repair a ‘broken heart’
aCardiology Division, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
bThe Institute of Genetic Medicine, Department of Medicine, Good Samaritan Hospital, University of Southern California, Los Angeles, CA, USA
cDepartment of Biochemistry and Molecular Biology, Good Samaritan Hospital, University of Southern California, Los Angeles, CA, USA
dThe Heart Institute, Good Samaritan Hospital, University of Southern California, Los Angeles, CA, USA
* Corresponding author. The Heart Institute, Good Samaritan Hospital, 1225 Wilshire Blvd., Los Angeles, CA 90017, USA. Tel.: +1 (213) 977 4050; fax: +1 (213) 977 4107.
Received 5 March 1997; accepted 27 May 1997
KEYWORDS Cardiomyocyte; Gene therapy; Myocardial infarction; Rat
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1 Introduction |
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Despite significant progress in prevention and therapy of ischemic heart disease, treating patients with heart failure after myocardial infarction remains a major therapeutic challenge. Adult cardiomyocytes cannot regenerate after injury. Therefore, cardiomyocyte loss due to myocardial infarction is irreversible. Currently, congestive heart failure is the only major cardiovascular disorder that is increasing in incidence and mortality [1]. Thus, there is still a need to develop alternative therapeutic strategies to prevent, arrest or reverse congestive heart failure after myocardial infarction.
Recent insights into the pathogenesis of myocardial disease and advances in molecular biology have opened up a new era of molecular and cellular therapies that target genes, molecules and peptides. Gene transfer as a therapeutic approach for the treatment of myocardial infarction and congestive heart failure has been suggested as a new treatment strategy for these serious disorders [2, 3]. The introduction, into injured myocardium, of recombinant transgenes that
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2 Post-infarction left ventricular dysfunction |
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3 Gene transfer into the ischemic or infarcted myocardium |
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4 Molecular cardiomyoplasty: gene therapy with MyoD |
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5 Cell transplant |
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6 Other strategies |
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7 Unresolved issues and challenges |
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8 Summary and future research |
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