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Cardiovascular Research 1997 35(2):202-205; doi:10.1016/S0008-6363(97)00072-2
© 1997 by European Society of Cardiology
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Copyright © 1997, European Society of Cardiology

Monitoring fibrillar collagen turnover in hypertensive heart disease

Javier Diéeza,* and Concepción Laviadesb

aVascular Pathophysiology Unit, School of Medicine, University of Navarra, Pamplona, Spain
bBlood Pressure Unit, Division of Nephrology, San Jorge General Hospital, Huesca, Spain

* Corresponding author. Unidad de Fisiopatologiéa Vascular, Facultad de Medicina, C/ Irunlarrea s/n, 31080 Pamplona, Spain. Tel.: +34 (48) 425600; fax: +34 (48) 425649.

Received 30 September 1996; accepted 7 November 1996

KEYWORDS Collagen; Hypertension; Fibroblasts; Extracellular matrix

The first 150 words of the full text of this article appear below.


   1 Hypertensive myocardial fibrosis
 
A substantial increase in fibrillar collagen has been observed in the cardiac ventricles of animals [1]and humans [2]with arterial hypertension. Either reactive or reparative hypertensive myocardial fibrosis is the result of both increased collagen types I and III synthesis by fibroblasts and unchanged or decreased extracellular collagen degradation [3]. Hemodynamic and non-hemodynamic factors may be involved in the disequilibrium between collagen synthesis and degradation that occurs in hypertension [4].

As shown experimentally [1]and clinically [5, 6], a rise in collagen content increases myocardial stiffness and promotes abnormalities of cardiac function. In addition, the perivascular accumulation of collagen fibers may impair the vasodilator capacity of intramyocardial coronary arteries and contribute to the decrease in coronary reserve, which is commonly seen in the hypertensive heart [7]. On the other hand, alterations in the electrical activity of the left ventricle in hypertensive patients have been shown . . . [Full Text of this Article]


   2 Biochemical assessment of fibrillar collagen synthesis and degradation
 
2.1 Fibrillar collagen synthesis
2.2 Fibrillar collagen degradation

   3 Fibrillar collagen synthesis and degradation-derived peptides in arterial hypertension
 
3.1 Animal studies
3.2 Human studies

   4 Discussion
 

   5 Conclusions and perspectives
 

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