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Cardiovascular Research Advance Access first published online on October 8, 2009
This version [Corrected Proof] published online on November 14, 2009
Cardiovascular Research, doi:10.1093/cvr/cvp333
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

On to the road to degradation: atherosclerosis and the proteasome

Joerg Herrmann1, Lilach O. Lerman2 and Amir Lerman1,*

1 Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
2 Division of Nephrology and Hypertension, Mayo Clinic Rochester, Rochester, MN, USA

* Corresponding author. Tel: +1 507 255 4152, Fax: +1 507 255 2550, Email: lerman.amir{at}mayo.edu

Protein metabolism is a central element of every living cell. The ubiquitin–proteasome system (UPS) is an integral part of the protein metabolism machinery mediating post-transcriptional processing and degradation of the majority of intracellular proteins. Over the past few years, remarkable progress has been made in our understanding of the role of the UPS in vascular biology and pathobiology, particularly atherosclerosis. This review reflects on the recent developments from the effects on endothelial cells and the initial stage of atherosclerosis to the effects on vascular smooth muscle and the progression stage of atherosclerosis and finally to the effects on cell viability and the complication stage of atherosclerosis. It will conclude with the integration of the available information in a synoptic view of the involvement of the UPS in atherosclerosis.

KEYWORDS Atherosclerosis; Inflammation; Oxidative stress; Proteasome; Ubiquitin

Time for primary review: 27 days

This article is part of the Spotlight Issue on: The Role of the Ubiquitin-Proteasome Pathway in Cardiovascular Disease


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