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Cardiovascular Research Advance Access first published online on September 30, 2009
This version [Corrected Proof] published online on October 27, 2009
Cardiovascular Research, doi:10.1093/cvr/cvp321
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

The ubiquitin-proteasome system in myocardial ischaemia and preconditioning

Saul R. Powell1,2,* and Andras Divald1

1 The Cardiac Metabolism Laboratory, The Feinstein Institute for Medical Research, Long Island Jewish Medical Center, 270-05 76th Avenue, Suite B-387, New Hyde Park, NY 11042, USA
2 Department of Medicine, The Albert Einstein College of Medicine, Bronx, NY, USA

* Corresponding author. Tel: +1 718 470 4724, Fax: +1 718 470 1732, Email: spowell{at}lij.edu

The ubiquitin-proteasome system (UPS) represents the major pathway for degradation of intracellular proteins. This article reviews the major components and configurations of the UPS including the 26S proteasome and 11S activated proteasome relevant to myocardial ischaemia. We then present the evidence that the UPS is dysfunctional during myocardial ischaemia as well as potential consequences of this, including dysregulation of target substrates, many of them active signalling proteins, and accumulation of oxidized proteins. As part of this discussion, potential mechanisms, including ATP depletion, inhibition by insoluble protein aggregates, and oxidation of proteasome and regulatory particle subunits, are discussed. Finally, the evidence suggesting a role for the UPS in ischaemic preconditioning is presented. Much of this is inferential but clearly indicates the need for additional research.

KEYWORDS Ubiquitin-proteasome system; Immunoproteasome; Myocardial ischaemia; Ischaemic preconditioning

Time for primary review: 23 days

This article is part of the Spotlight Issue on: The Role of the Ubiquitin-Proteasome Pathway in Cardiovascular Disease


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