Skip Navigation


Cardiovascular Research Advance Access first published online on November 3, 2008
This version [Corrected Proof] published online on November 23, 2008
Cardiovascular Research, doi:10.1093/cvr/cvn294
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
81/2/362    most recent
cvn294v2
cvn294v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Zheng, P.-P.
Right arrow Articles by Kros, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zheng, P.-P.
Right arrow Articles by Kros, J. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org.

A crucial role of caldesmon in vascular development in vivo

Ping-Pin Zheng1, Lies-Anne Severijnen2, Marcel van der Weiden1, Rob Willemsen2,{dagger} and Johan M. Kros1,*,{dagger}

1 Department of Pathology, Erasmus Medical Center, JNI Room 230-c, Dr Molewaterplein 50, PO Box 1738, 3000 DR Rotterdam, The Netherlands
2 Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands

* Corresponding author. Tel: +31 10 7043905; fax: +31 10 7043905. E-mail address: j.m.kros{at}erasmusmc.nl

Aims: We explored the in vivo effects of knockdown of caldesmon on vascular development in zebrafish.

Methods and results: We investigated the effects of caldesmon knockdown on the vascular development in a zebrafish model with special attention for the trunk and head vessels including the aortic arches. We examined the developing fishes at various time points. The vascular abnormalities observed in the caldesmon morphants were morphologically and functionally characterized in detail in fixed and living embryos. The knockdown of caldesmon caused serious defects in vasculogenesis and angiogenesis in zebrafish morphants, and the vascular integrity and blood circulation were concomitantly impaired.

Conclusion: The data provide the first functional assessment of the role of caldesmon in vascular development in vivo, indicating that this molecule plays a crucial role in vasculogenesis and angiogenesis in vivo. Interfering with caldesmon opens new therapeutic avenues for anti-angiogenesis in cancer and ischaemic cardiovascular disease.

KEYWORDS Caldesmon; Vascular development; Zebrafish model; Vasculogenesis; Angiogenesis

Time for primary review: 13 days

{dagger} These authors contributed equally to this work.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CirculationHome page
P.-P. Zheng, L.-A. Severijnen, R. Willemsen, and J. M. Kros
Functional Cardiac Phenotypes in Zebrafish Caldesmon Morphants: A Digital Motion Analysis
Circulation, October 27, 2009; 120(17): e145 - e146.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.