Skip Navigation


Cardiovascular Research Advance Access first published online on October 31, 2008
This version [Corrected Proof] published online on December 4, 2008
Cardiovascular Research, doi:10.1093/cvr/cvn292
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrowOA All Versions of this Article:
81/3/474    most recent
cvn292v2
cvn292v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Frantz, S.
Right arrow Articles by Ertl, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frantz, S.
Right arrow Articles by Ertl, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org.

Post-infarct remodelling: contribution of wound healing and inflammation

Stefan Frantz, Johann Bauersachs and Georg Ertl*

Medizinische Klinik und Poliklinik I, Universitätsklinikum Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany

* Corresponding author. Tel: +49 931 201 36301; Fax: +49 931 201 36302.E-mail address: ertl_g{at}medizin.uni-wuerzburg.de

In human and experimental myocardial infarction (MI), cessation of blood supply leads to rapid necrosis of cardiac myocytes in the ischaemic heart. Immediately after injury, various intra- and intercellular pathways contribute to healing the myocardial wound in order to achieve tissue integrity and function. MI and the consequent loss of myocardium are the major aetiology for heart failure. Despite aggressive primary therapy, prognosis remains poor in patients with large infarction and severe left ventricular dysfunction. Thus, it would be highly desirable to improve healing of the cardiac wound to maintain structure and function of the heart. Healing in the heart occurs in overlapping phases. Herein, we review the inflammatory phase as a trigger of tissue formation.

KEYWORDS Myocardial infarction; Healing; Inflammation

Time for primary review: 24 days


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
S. Apostolakis, G. Y.H. Lip, and E. Shantsila
Monocytes in heart failure: relationship to a deteriorating immune overreaction or a desperate attempt for tissue repair?
Cardiovasc Res, October 28, 2009; (2009) cvp327v2.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. Diez and G. Ertl
A translational approach to myocardial remodelling
Cardiovasc Res, February 15, 2009; 81(3): 409 - 411.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.