Skip Navigation


Cardiovascular Research Advance Access first published online on August 14, 2008
This version [Corrected Proof] published online on September 4, 2008
Cardiovascular Research, doi:10.1093/cvr/cvn229
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Data
Right arrow All Versions of this Article:
81/3/555    most recent
cvn229v3
cvn229v2
cvn229v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Mou, Y. A.
Right arrow Articles by Cazorla, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mou, Y. A.
Right arrow Articles by Cazorla, O.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Late exercise training improves non-uniformity of transmural myocardial function in rats with ischaemic heart failure

Younss Aït Mou1,2, Cyril Reboul3, Lucas Andre1,2, Alain Lacampagne1,2 and Olivier Cazorla1,2,*

1 INSERM U637, Physiopathologie Cardiovasculaire, CHU Arnaud de Villeneuve, 34295 Montpellier Cedex 5, Montpellier, France
2 Université Montpellier1, UFR de Médecine, F-34295 Montpellier, France
3 EA-4278, Université Avignon et des Pays de Vaucluse, UFR Sciences F-84000, Avignon, France

* Corresponding author. Tel: +33 467 41 52 42; fax: +33 467 41 52 42. E-mail address: olivier.cazorla{at}inserm.fr

Aims: The exercise-induced beneficial mechanisms after long-term myocardial infarction (MI) are incompletely understood. The present study evaluated the effect of treadmill exercise training (5 weeks), started at a late stage of heart failure (HF) (13 weeks post-MI), on rat left ventricle remodelling and dysfunction of the regional global and cellular contractile functions.

Methods and results: In vivo echocardiography confirmed that sub-endocardial (ENDO) layers contract more (+86%) and faster (+50%) than the sub-epicardial (EPI) layers. This gradient was lost in MI rats due to a predominant reduction in the ENDO layer contractility. Exercise partially restored the amplitude and velocity of ENDO contraction, resulting in a partial recovery of the pump function indexed by the aortic blood-flow velocity time integral. At the cellular level, MI impaired ENDO contractile properties by reducing cell shortening (10–7%), calcium transient, and myofilament Ca2+ sensitivity. These alterations were normalized by exercise. Sarcoplasmic reticulum Ca2+-ATPase (SERCA)2a expression and myosin light chain (MLC)-2 phosphorylation in ENDO cells were significantly reduced after MI and were restored by exercise. The EPI layer was only slightly reduced in vivo without cellular alterations.

Conclusion: This study shows that exercise performed at a late stage after MI restored a transmural non-uniformity of myocardium lost during HF. Recoveries of Ca2+ homeostasis and myofilament function of cardiomyocytes contribute to this beneficial effect.

KEYWORDS End-stage heart failure; Myocardial contractility; Contraction; Exercise; Myocardial infarction

Time for primary review: 27 days


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Circ Heart FailHome page
D. J. Duncker, N. M. Boontje, D. Merkus, A. Versteilen, J. Krysiak, G. Mearini, A. El-Armouche, V. J. de Beer, J. M.J. Lamers, L. Carrier, et al.
Prevention of Myofilament Dysfunction by {beta}-Blocker Therapy in Postinfarct Remodeling
Circ Heart Fail, May 1, 2009; 2(3): 233 - 242.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.