Skip Navigation


Cardiovascular Research Advance Access first published online on April 22, 2008
This version [Corrected Proof] published online on May 2, 2008
Cardiovascular Research, doi:10.1093/cvr/cvn098
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
79/2/208    most recent
cvn098v2
cvn098v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ventura-Clapier, R.
Right arrow Articles by Veksler, V.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ventura-Clapier, R.
Right arrow Articles by Veksler, V.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1{alpha}

Renée Ventura-Clapier1,2,*, Anne Garnier1,2 and Vladimir Veksler1,2

1 Faculté de Pharmacie, INSERM U-769, F-92296 Châtenay-Malabry, France
2 Université Paris-Sud, IFR141, F-92296 Châtenay-Malabry, France

* Corresponding author. Tel: +33 1 46 83 57 62; fax: +33 1 46 83 54 75. E-mail address: renee.ventura{at}u-psud.fr

Although the concept of energy starvation in the failing heart was proposed decades ago, still very little is known about the origin of energetic failure. Recent advances in molecular biology have started to elucidate the transcriptional events governing mitochondrial biogenesis. In particular, a great step was taken with the discovery that peroxisome proliferator-activated receptor gamma co-activator (PGC-1{alpha}) is the master regulator of mitochondrial biogenesis. The molecular mechanisms underlying the downregulation of PGC-1{alpha} and the consequent decrease in mitochondrial function in heart failure are, however, still poorly understood. Indeed, the main pathways involved in mitochondrial biogenesis are thought to be up- rather than down-regulated in pathological hypertrophy and heart failure. The current review summarizes recent advances in this field and is restricted to the heart when cardiac data are available.

KEYWORDS Mitochondrial biogenesis; Signalling pathways; Heart failure; Cardiovascular diseases; Energy metabolism

Time for primary review: 31 days


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
G. D. Lopaschuk and D. P. Kelly
Signalling in cardiac metabolism
Cardiovasc Res, July 15, 2008; 79(2): 205 - 207.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.