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Cardiovascular Research Advance Access originally published online on February 13, 2009
Cardiovascular Research 2009 83(2):179-194; doi:10.1093/cvr/cvp062
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Cardioprotective growth factors

Derek J. Hausenloy and Derek M. Yellon*

The Hatter Cardiovascular Institute, University College London Hospital and Medical School, 67 Chenies Mews, London WC1E 6HX, UK

* Corresponding author. Tel: +44 207 380 9888; fax: +44 207 380 9505. E-mail address: hatter-institute{at}ucl.ac.uk

Many of the originally identified cardiovascular ‘growth factors’ have been demonstrated to exert a diverse variety of actions within the cardiovascular system, the majority of which are unrelated to their initially proposed mechanism of action. Interestingly, several of these growth factors have been demonstrated to protect the cardiomyocyte from the detrimental effects of acute ischaemia–reperfusion injury, through the activation of a variety of cell-surface receptors and the subsequent recruitment of a number of intracellular signal transduction pathways, which include components of the reperfusion injury salvage kinase pathway. This article will review several of these cardioprotective growth factors with respect to their ability to confer direct myocardial protection, focusing on the underlying signalling pathways involved and their potential for clinical application.

KEYWORDS Cardioprotection; Ischaemia; Reperfusion; Growth factors

Time for primary review: 23 days


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