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Cardiovascular Research Advance Access originally published online on November 26, 2008
Cardiovascular Research 2009 82(2):261-271; doi:10.1093/cvr/cvn325
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org.

Phosphoinositide 3-kinase signalling in the vascular system

Fulvio Morello{dagger}, Alessia Perino{dagger} and Emilio Hirsch*

Molecular Biotechnology Center, University of Torino, via Nizza 52, 10126 Torino, Italy

* Corresponding author. Tel: +39 011 6706425; fax: +39 011 6706432. E-mail address: emilio.hirsch{at}unito.it

Phosphoinositide 3-kinases (PI3Ks) are protein and lipid kinases activated by different classes of membrane receptors, including G-protein coupled and tyrosine kinase receptors. Several lines of evidence have uncovered specific roles for distinct PI3K isoforms in the vascular system in both physiology and disease. The present review will summarize and discuss the most recent advances regarding PI3K-Akt signalling in endothelial cells, vascular smooth muscle cells, platelets, and inflammatory cells involved in the atherosclerotic process. Of interest, the development of novel isoform-selective PI3K inhibitor drugs offers a unique opportunity to selectively and differentially target PI3K-driven pathways in the vascular system and may give rise to new strategies for the treatment of cardiovascular diseases.

KEYWORDS Vascular system; Signal transduction; Endothelium; Smooth muscle; Platelets; Atherosclerosis

Time for primary review: 27 days

{dagger} F.M. and A.P. equally contributed to this work.


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