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Cardiovascular Research Advance Access originally published online on October 31, 2008
Cardiovascular Research 2009 81(3):474-481; doi:10.1093/cvr/cvn292
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org
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Post-infarct remodelling: contribution of wound healing and inflammation

Stefan Frantz, Johann Bauersachs and Georg Ertl*

Medizinische Klinik und Poliklinik I, Universitätsklinikum Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany

* Corresponding author. Tel: +49 931 201 36301; Fax: +49 931 201 36302.E-mail address: ertl_g{at}medizin.uni-wuerzburg.de

In human and experimental myocardial infarction (MI), cessation of blood supply leads to rapid necrosis of cardiac myocytes in the ischaemic heart. Immediately after injury, various intra- and intercellular pathways contribute to healing the myocardial wound in order to achieve tissue integrity and function. MI and the consequent loss of myocardium are the major aetiology for heart failure. Despite aggressive primary therapy, prognosis remains poor in patients with large infarction and severe left ventricular dysfunction. Thus, it would be highly desirable to improve healing of the cardiac wound to maintain structure and function of the heart. Healing in the heart occurs in overlapping phases. Herein, we review the inflammatory phase as a trigger of tissue formation.

KEYWORDS Myocardial infarction; Healing; Inflammation

Time for primary review: 24 days


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