Skip Navigation


Cardiovascular Research Advance Access originally published online on April 5, 2008
Cardiovascular Research 2008 79(2):238-248; doi:10.1093/cvr/cvn093
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
79/2/238    most recent
cvn093v2
cvn093v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (12)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Bertrand, L.
Right arrow Articles by Vanoverschelde, J.-L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bertrand, L.
Right arrow Articles by Vanoverschelde, J.-L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Insulin signalling in the heart

Luc Bertrand1,*, Sandrine Horman1,2, Christophe Beauloye1 and Jean-Louis Vanoverschelde1

1 CARD Unit, Division of Cardiology, Université catholique de Louvain, 55, Avenue Hippocrate, CARD5550, 1200 Brussels, Belgium
2 Hormone and Metabolic Research Unit, de Duve Institute, Université catholique de Louvain, Brussels, Belgium

* Corresponding author. Tel: +32 2 764 55 52; fax: +32 2 764 55 36. E-mail address: luc.bertrand{at}uclouvain.be

The main role of insulin in the heart under physiological conditions is obviously the regulation of substrate utilization. Indeed, insulin promotes glucose uptake and its utilization via glycolysis. In addition, insulin participates in the regulation of long-chain fatty acid uptake, protein synthesis, and vascular tonicity. Significant advancements have been made over the last 20 years in the understanding of the signal transduction elements involved in these insulin effects. Among these molecular mechanisms, the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway is thought to play a crucial role. Under pathological conditions, such as type-2 diabetes, myocardial ischaemia, and cardiac hypertrophy, insulin signal transduction pathways and action are clearly modified. These molecular signalling alterations are often linked to atypical crosstalks with other signal transduction pathways. On the other hand, pharmacological modifications of parallel and interdependent signalling components, such as the AMP-activated protein kinase pathway, are now considered to be a good therapeutic approach to treat insulin-signalling defects such as insulin resistance and type-2 diabetes. In this review, we will focus on the description of the molecular signalling elements involved in insulin action in the heart and vasculature under these different physiological, pathological, and therapeutical conditions.

KEYWORDS Energy metabolism; PKB/Akt; Ischaemia; Protein synthesis; Insulin resistance; AMPK

Time for primary review: 21 days


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
H.-Y. Liu, J. Han, S. Y. Cao, T. Hong, D. Zhuo, J. Shi, Z. Liu, and W. Cao
Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia: INHIBITION OF FoxO1-DEPENDENT EXPRESSION OF KEY AUTOPHAGY GENES BY INSULIN
J. Biol. Chem., November 6, 2009; 284(45): 31484 - 31492.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
P.-S. Tsou, V. Addanki, J. A. Haas, N. A. Page, and H.-L. Fung
Role of Glutaredoxin-Mediated Protein S-Glutathionylation in Cellular Nitroglycerin Tolerance
J. Pharmacol. Exp. Ther., May 1, 2009; 329(2): 649 - 656.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J.-Y. Youn, T. Wang, and H. Cai
An Ezrin/Calpain/PI3K/AMPK/eNOSs1179 Signaling Cascade Mediating VEGF-Dependent Endothelial Nitric Oxide Production
Circ. Res., January 2, 2009; 104(1): 50 - 59.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. D. Vaughan-Jones and P. Swietach
Pushing and Pulling the Cardiac Sodium/Hydrogen Exchanger
Circ. Res., October 10, 2008; 103(8): 773 - 775.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
G. D. Lopaschuk and D. P. Kelly
Signalling in cardiac metabolism
Cardiovasc Res, July 15, 2008; 79(2): 205 - 207.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.