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Cardiovascular Research Advance Access originally published online on March 7, 2008
Cardiovascular Research 2008 79(2):218-227; doi:10.1093/cvr/cvn061
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Genomics in cardiac metabolism

Jane-Lise Samuel1,2, Marcus C. Schaub3, Michael Zaugg4, Mamas Mamas5, Warwick B. Dunn6 and Bernard Swynghedauw1,2,*

1 U689 INSERM, Hôpital Lariboisière, 41 Bd de la Chapelle, 75475 Paris Cedex 10, France
2 Université Denis Diderot, Paris Cedex 7, France
3 Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
4 Institute of Anaesthesiology, University Hospital Zurich, Zurich, Switzerland
5 Department of Cardiology, Manchester Royal Infirmary, Manchester, UK
6 The Manchester Centre for Integrative Systems Biology, University of Manchester, Manchester, UK

* Corresponding author. Tel: +33 1 5321 6760; fax: +33 1 53 21 67 39. E-mail address: bernard.swynghedauw{at}larib.inserm.fr

Cell biology is in transition from reductionism to a more integrated science. Large-scale analysis of genome structure, gene expression, and metabolites are new technologies available for studying cardiac metabolism in diseases known to modify cardiac function. These technologies have several limitations and this review aims both to assess and take a critical look at some important results obtained in genomics restricted to molecular genetics, transcriptomics and metabolomics of cardiac metabolism in pathophysiological processes known to alter myocardial function. Therefore, our goal was to delineate new signalling pathways and new areas of research from the vast amount of data already published on genomics as applied to cardiac metabolism in diseases such as coronary heart disease, heart failure, and ischaemic reperfusion.

KEYWORDS Cardiac metabolism; Genome-wide analysis; Metabolomics; Transcriptomics

Time for primary review: 15 days


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