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Cardiovascular Research Advance Access originally published online on February 19, 2008
Cardiovascular Research 2008 78(2):213-222; doi:10.1093/cvr/cvn045
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Besides adhesion: new perspectives of integrin functions in angiogenesis

Guido Serini, Lucia Napione, Marco Arese and Federico Bussolino*

Department of Oncological Sciences, Institute for Cancer Research and Treatment, University of Torino, Sp 142, Km 3.95, 10060 Candiolo, Torino, Italy

* Corresponding author. Tel: +39 0119933347; fax: +39 09119933524. E-mail address: federico.bussolino{at}unito.it

During angiogenic remodelling in embryo and adult life, endothelial cells lining blood vessel walls dynamically modify their integrin-mediated adhesive contacts with the surrounding extracellular matrix. However, besides regulating cell adhesion and migration, integrins dynamically participate in a network with soluble molecules and their receptors. Angiogenesis is characterized by opposing autocrine and paracrine loops of growth factors and semaphorins that regulate the activation of integrins on the endothelial surface through tyrosine kinase receptors (TKR) and the neuropilin/plexin system. Moreover, pro- and anti-angiogenic factors can directly bind integrins and regulate endothelial cell behaviour. This review summarizes the recent progress in understanding the reciprocal interactions between integrins, TKR, and semaphorin receptors.

KEYWORDS Plexin; Semaphorin; Tyrosine kinase receptors; Endothelial cells

Time for primary review: 11 days


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