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Cardiovascular Research Advance Access originally published online on December 12, 2007
Cardiovascular Research 2008 78(1):18-25; doi:10.1093/cvr/cvm101
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

Cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction

Rutger J. Hassink1,*, Kishore B. Pasumarthi2,3, Hidehiro Nakajima2,3, Michael Rubart2,3, Mark H. Soonpaa2,3, Aart Brutel de la Rivière4, Pieter A. Doevendans1 and Loren J. Field2,3

1 Department of Cardiology, University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
2 The Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202-5225, USA
3 Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202-5225, USA
4 Department of Cardio-thoracic Surgery, University Medical Center, Heidelberglaan 100, 3584, CX, Utrecht, The Netherlands

* Corresponding author: Tel: +31 73 6992000; fax: +31 73 6992763. E-mail address: rjhassink{at}orange.nl; rjhassink{at}wanadoo.nl

Aims: Cardiomyocyte loss is a major contributor to the decreased cardiac function observed in diseased hearts. Previous studies have shown that cardiomyocyte-restricted cyclin D2 expression resulted in sustained cell cycle activity following myocardial injury in transgenic (MHC-cycD2) mice. Here, we investigated the effects of this cell cycle activation on cardiac function following myocardial infarction (MI).

Methods and results: MI was induced in transgenic and non-transgenic mice by left coronary artery occlusion. At 7, 60, and 180 days after MI, left ventricular pressure–volume measurements were recorded and histological analysis was performed. MI had a similar adverse effect on cardiac function in transgenic and non-transgenic mice at 7 days post-injury. No improvement in cardiac function was observed in non-transgenic mice at 60 and 180 days post-MI. In contrast, the transgenic animals exhibited a progressive and marked increase in cardiac function at subsequent time points. Improved cardiac function in the transgenic mice at 60 and 180 days post-MI correlated positively with the presence of newly formed myocardial tissue which was not apparent at 7 days post-MI. Intracellular calcium transient imaging indicated that cardiomyocytes present in the newly formed myocardium participated in a functional syncytium with the remote myocardium.

Conclusion: These findings indicate that cardiomyocyte cell cycle activation leads to improvement of cardiac function and morphology following MI and may represent an important clinical strategy to promote myocardial regeneration.

KEYWORDS Cardiomyocyte cell cycle activation; Cardiac regeneration; Myocardial infarction; Cardiac function

Time for primary review: 20 days


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