Cardiovascular Research Advance Access originally published online on September 20, 2007
Cardiovascular Research 2008 77(1):89-97; doi:10.1093/cvr/cvm024
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Long chain n-3 polyunsaturated fatty acids reduce atrial vulnerability in a novel canine pacing model
1 Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON, Canada
2 Division of Cardiology, St Michael’s Hospital, 30 Bond Street, 6-050Q, Toronto, ON, Canada M5B 1W8
3 Department of Medicine, University of Toronto, Toronto, ON, Canada
4 Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
5 Bioimaging, St Michael’s Hospital, Toronto, ON, Canada
6 Department of Medicine, St Vincent’s Hospital, University of Melbourne, Victoria, Australia
7 Department of Surgery, University of Toronto, Toronto, ON, Canada
8 Terrence Donnelly Cardiovascular Laboratories, St Michael’s Hospital, Toronto, ON, Canada
9 Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
* Corresponding author. Tel/Fax: +1 416 864 5104. E-mail address: dorianp{at}smh.toronto.on.ca
Aim: Our objective was to assess the effect of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on atrial fibrillation (AF) vulnerability and atrial structure in a new model of atrial cardiomyopathy.
Methods and results: Dogs were studied in three groups: seven control dogs (UNPACED) and 24 dogs undergoing simultaneous atrioventricular pacing (for 2 weeks) assigned to placebo treatment (SAVP-PLACEBO, n = 12 dogs) or oral n-3 PUFAs (1 g/day) treatment (SAVP-PUFA, n = 12 dogs). SAVP-PUFA dogs had less AF inducibility (percentage of burst attempts leading to AF episodes: 5.5 ± 7.4 vs. 20.4 ± 14.2, P < 0.001) and maintenance [median AF duration: 601 s (377–1216) vs. 1598 s (1195–2400), P < 0.05] than SAVP-PLACEBO dogs. SAVP-PUFA dogs had significantly less local slowing of conduction and conduction heterogeneity than SAVP-PLACEBO dogs. SAVP-PUFA dogs had a significantly smaller increase in atrial matrix metalloproteinase-9 activity and in collagen type I and III messenger RNA expression (in arbitrary units) than SAVP-PLACEBO dogs (0.62 ± 0.51 vs. 10.80 ± 5.61, respectively for collagen I, P < 0.05; 1.66 ± 0.48 vs. 5.24 ± 1.16, respectively, for collagen III, P < 0.05).
Conclusion: n-3 PUFA supplementation can reduce AF vulnerability in a new canine pacing model of atrial cardiomyopathy. The mechanism may be related to attenuation of collagen turnover.
KEYWORDS Polyunsaturated fatty acids; atrial fibrillation; canine pacing model; collagen
Time for primary review 33 days
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  P. Dorian and B. N. Singh Upstream therapies to prevent atrial fibrillation Eur. Heart J. Suppl., September 1, 2008; 10(suppl_H): H11 - H31. [Abstract] [Full Text] [PDF]
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