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Cardiovascular Research 2007 75(3):468-477; doi:10.1016/j.cardiores.2007.03.010
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Copyright © 2007, European Society of Cardiology

CD36 and macrophages in atherosclerosis

Sophie Collot-Teixeiraa,b,*, Juliette Martina,b, Chris McDermott-Roeb, Robin Postona and John Louis McGregora,b,c

a Cardiovascular Division, King's College, London, UK
b Thrombosis Research Institute, London, UK
c INSERM Unit 689, Hôpital Lariboisière, Paris, France

* Corresponding author. Cardiovascular Division, King's College London, Waterloo Campus, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK. Tel.: +44 20 7848 4281; fax: +44 20 7848 3743. sophie.collot{at}kcl.ac.uk

CD36 is a multi-ligand scavenger receptor present on the surface of a number of cells such as platelets, monocytes/macrophages, endothelial and smooth muscle cells. Monocyte/macrophage CD36 has been shown to play a critical role in the development of atherosclerotic lesions by its capacity to bind and endocytose oxidized low density lipoproteins (OxLDL), and it is implicated in the formation of foam cells. However, the significance of CD36 in atherosclerosis has recently been called into question by different studies, and therefore its exact role still needs to be clarified. The aim of this article is to carefully review the importance of CD36 as an essential component in the pathogenesis of atherosclerosis.

KEYWORDS CD36; Vascular; Monocyte/macrophages; OxLDL; Atherosclerosis


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