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Cardiovascular Research 2007 75(1):10-20; doi:10.1016/j.cardiores.2007.02.029
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Copyright © 2007, European Society of Cardiology

Do statins have an antiarrhythmic activity?

M.S. Kostapanosa, E.N. Liberopoulosa, J.A. Goudevenosb, D.P. Mikhailidisc and M.S. Elisafa,*

aDepartment of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
bDepartment of Cardiology, School of Medicine, University of Ioannina, Ioannina, Greece
cDepartment of Clinical Biochemistry, Royal Free Hospital University College Medical School, University of London, London, UK

* Corresponding author. Tel.: +30 26510 97509; fax: +30 26510 97016. egepi{at}cc.uoi.gr

Sudden cardiac death, which is mainly associated with the presence of life-threatening ventricular arrhythmias, is a common ‘killer’ among patients with coronary artery disease. Moreover, atrial fibrillation is the most common arrhythmia encountered in the clinical practice. The beneficial effect of statins on cardiovascular morbidity and mortality is well-established, while the exact role of this class of drugs against arrhythmias remains unclear.

This review discusses the effect of statin treatment on arrhythmias that are commonly seen in the clinical setting. The underlying pathophysiological mechanisms are also overviewed. Compelling evidence from the majority of the studies reviewed shows that statins exhibit a protective effect against the occurrence of ventricular arrhythmias and atrial fibrillation.

KEYWORDS Statins; Arrhythmias (mechanisms); Sudden death


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