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Cardiovascular Research 2007 74(2):244-255; doi:10.1016/j.cardiores.2006.11.022
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Copyright © 2006, European Society of Cardiology

Role of bone morphogenetic proteins in cardiac differentiation

Bram van Wijk, Antoon F.M. Moorman and Maurice J.B. van den Hoff*

Molecular and Experimental Cardiology Group, Department of Anatomy and Embryology, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

* Corresponding author. Tel.: +31 20 5665378; fax: +31 20 6976177. Email address: m.j.vandenhoff{at}amc.uva.nl

Bone morphogenetic proteins (BMP) are involved in the regulation of a plethora of processes underlying cardiovascular development. This review summarizes the effects of BMP and the signaling pathways that regulate the differentiation of cardiomyocytes from mesoderm in the heart-forming region and at the distal borders of the heart tube from the second heart field. Subsequently, the role of BMPs in the formation of the ventricular chambers and septovalvulogenesis in the atrioventricular canal and outflow tract is described. Finally, the effects of BMPs in stem cell biology and cardiac regeneration are discussed.

KEYWORDS BMP signaling; Cardiovascular development; Septation; Chamber formation

Time for primary review 16 days


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