Skip Navigation

Cardiovascular Research 2006 72(2):198-209; doi:10.1016/j.cardiores.2006.06.025
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Brade, T.
Right arrow Articles by Kühl, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brade, T.
Right arrow Articles by Kühl, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2006, European Society of Cardiology

The role of Wnt signalling in cardiac development and tissue remodelling in the mature heart

Thomas Bradea, Jörg Männerb and Michael Kühla,*

aDepartment of Biochemistry and Molecular Biology, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany
bDepartment of Anatomy and Embryology, University of Göttingen, Kreuzbergring 36, D-37075 Göttingen, Germany

* Corresponding author. Tel.: +49 731 500 23283; fax: +49 731 500 23277. Email address: michael.kuehl{at}uni-ulm.de

The heart is one of the first organs to function in the developing embryo. Vertebrate heart development can be subdivided into different phases, e.g. specification of myo- and endocardial progenitor cells during the establishment of heart-forming fields within the anterior lateral plate mesoderm, formation of the linear heart tube by merging of the paired heart-forming fields in front of the foregut, looping of the heart tube and transformation of the tubular embryonic heart into the four-chambered heart. The molecular mechanisms underlying these processes are phylogenetically remarkably conserved and involve the activation of specific transcriptional programs by different extracellular growth factors. In this review, we will focus on the functions of the Wnt family of growth factors in normal cardiac development and in tissue remodelling in the mature heart under pathological conditions.

KEYWORDS Wnt; Frizzled; Cardiac development; Cardiac specification; Cardiac morphogenesis; Cardiac remodelling

Time for primary review 22 days


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.