Copyright © 2006, European Society of Cardiology
Regulating cellular oxygen sensing by hydroxylation
aInstitut für Physiologie, Universität Duisburg-Essen, Hufelandstrasse 55, D-45122 Essen, Germany
bInstitute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland
* Corresponding author. Tel./fax: +49 201 723 4600/4648. Email address: joachim.fandrey{at}uni-due.de
Oxygen homeostasis under conditions of limited O2 supply requires hypoxia-dependent gene regulation. The transcription factor complex hypoxia-inducible factor 1 (HIF-1) has been recognized as the master regulator that mediates the adaptational genetic response to ensure restoration of energy supply. This review will focus on the recent advances in understanding the hypoxia-induced cellular response with particular respect to cellular O2 sensing for adequate control of HIF-1 activation.
KEYWORDS HIF-1; Hypoxia; Hypoxia-induced gene expression
1 PAS: acronym for PER, ARNT, SIM, the first proteins discovered to contain this domain.
Time for primary review 28 days
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