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Cardiovascular Research 2006 71(2):289-299; doi:10.1016/j.cardiores.2006.05.004
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Copyright © 2006, European Society of Cardiology

NADPH oxidases: New kids on the block

Miklós Geiszt*

Department of Physiology, Semmelweis University, Faculty of Medicine, PO Box 259, H-1444 Budapest, Hungary

* Tel.: +36 20 825 4109; fax: +36 1 266 7480. Email address: geiszt{at}puskin.sote.hu

Reactive oxygen species (ROS) play a pivotal role in many physiological processes including host defense, hormone biosynthesis, fertilization and cellular signaling. Altered production of ROS has been implicated in the development of immunodeficiency, hypothyroidism and cardiovascular pathologies. In the last few years, several enzymes were identified at the molecular level, which are now thought to be responsible for ROS production observed in diverse tissues. These enzymes show a high degree of homology to the phagocytic NADPH oxidase and are now designated the Nox family of NADPH oxidases. This review updates our knowledge on six new members of the Nox family: Nox1, Nox3, Nox4, Nox5, Duox1 and Duox2.

KEYWORDS NADPH oxidase; Nox; Duox; Superoxide; Reactive oxygen species (ROS)

Time for primary review 25 days


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