Copyright © 2006, European Society of Cardiology
NADPH oxidases: New kids on the block
Department of Physiology, Semmelweis University, Faculty of Medicine, PO Box 259, H-1444 Budapest, Hungary
* Tel.: +36 20 825 4109; fax: +36 1 266 7480. Email address: geiszt{at}puskin.sote.hu
Reactive oxygen species (ROS) play a pivotal role in many physiological processes including host defense, hormone biosynthesis, fertilization and cellular signaling. Altered production of ROS has been implicated in the development of immunodeficiency, hypothyroidism and cardiovascular pathologies. In the last few years, several enzymes were identified at the molecular level, which are now thought to be responsible for ROS production observed in diverse tissues. These enzymes show a high degree of homology to the phagocytic NADPH oxidase and are now designated the Nox family of NADPH oxidases. This review updates our knowledge on six new members of the Nox family: Nox1, Nox3, Nox4, Nox5, Duox1 and Duox2.
KEYWORDS NADPH oxidase; Nox; Duox; Superoxide; Reactive oxygen species (ROS)
Time for primary review 25 days
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. Muteliefu, A. Enomoto, P. Jiang, M. Takahashi, and T. Niwa Indoxyl sulphate induces oxidative stress and the expression of osteoblast-specific proteins in vascular smooth muscle cells Nephrol. Dial. Transplant., July 1, 2009; 24(7): 2051 - 2058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gao and G. E. Mann Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling Cardiovasc Res, April 1, 2009; 82(1): 9 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Basuroy, S. Bhattacharya, C. W. Leffler, and H. Parfenova Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-{alpha} in cerebral vascular endothelial cells Am J Physiol Cell Physiol, March 1, 2009; 296(3): C422 - C432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Koh, P. C. Oh, and M. J. Quon Does reversal of oxidative stress and inflammation provide vascular protection? Cardiovasc Res, March 1, 2009; 81(4): 649 - 659. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kawahara and J. D. Lambeth Phosphatidylinositol (4,5)-bisphosphate Modulates Nox5 Localization via an N-Terminal Polybasic Region Mol. Biol. Cell, October 1, 2008; 19(10): 4020 - 4031. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Sly, J. Kalesnikoff, V. Lam, D. Wong, C. Song, S. Omeis, K. Chan, C. W. K. Lee, R. P. Siraganian, J. Rivera, et al. IgE-Induced Mast Cell Survival Requires the Prolonged Generation of Reactive Oxygen Species J. Immunol., September 15, 2008; 181(6): 3850 - 3860. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Block, A. Eid, K. K. Griendling, D.-Y. Lee, Y. Wittrant, and Y. Gorin Nox4 NAD(P)H Oxidase Mediates Src-dependent Tyrosine Phosphorylation of PDK-1 in Response to Angiotensin II: ROLE IN MESANGIAL CELL HYPERTROPHY AND FIBRONECTIN EXPRESSION J. Biol. Chem., August 29, 2008; 283(35): 24061 - 24076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Nauseef Biological Roles for the NOX Family NADPH Oxidases J. Biol. Chem., June 20, 2008; 283(25): 16961 - 16965. [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Martins, V. M. Shkryl, M. C. Nowycky, and N. Shirokova Reactive oxygen species contribute to Ca2+ signals produced by osmotic stress in mouse skeletal muscle fibres J. Physiol., January 1, 2008; 586(1): 197 - 210. [Abstract] [Full Text] [PDF]
|
|