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Cardiovascular Research 2006 71(2):259-268; doi:10.1016/j.cardiores.2006.03.002
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Copyright © 2006, European Society of Cardiology

DNA damage and repair in atherosclerosis

Melli Mahmoudi, John Mercer and Martin Bennett*

Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK

* Corresponding author. Tel.: +44 1223 331504; fax: +44 1223 331505. Email address: mrb{at}mole.bio.cam.ac.uk

There is increasing evidence that human atherosclerosis is associated with damage to the DNA of both circulating cells, and cells of the vessel wall. Reactive oxygen species are the most likely agents inducing DNA damage in atherosclerosis. DNA damage produces a variety of responses, including cell senescence, apoptosis and DNA repair. This review summarises the evidence for DNA damage in atherosclerosis, the cellular responses to damage and the mechanisms of signalling DNA damage.

KEYWORDS Atherosclerosis; Oxygen radicals

Time for primary review 11 days


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