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Cardiovascular Research 2006 71(2):216-225; doi:10.1016/j.cardiores.2006.02.033
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Copyright © 2006, European Society of Cardiology

Reactive oxygen species signaling in vascular smooth muscle cells

Roza E. Clempus and Kathy K. Griendling*

Department of Medicine, Division of Cardiology, Emory University, 319 WMB, 1639 Pierce Dr. Atlanta, GA 30322, United States

* Corresponding author. Tel.: +1 404 727 3364; fax: +1 404 727 3585. Email address: kgriend{at}emory.edu

Reactive oxygen species (ROS) have been shown to function as important signaling molecules in the cardiovascular system. Vascular smooth muscle cells (VSMCs) contain several sources of ROS, among which the NADPH oxidases are predominant. In VSMCs, ROS mediate many pathophysiological processes, such as growth, migration, apoptosis and secretion of inflammatory cytokines, as well as physiological processes, such as differentiation, by direct and indirect effects at multiple signaling levels. Therefore, it becomes critical to understand the different roles ROS play in the physiology and pathophysiology of VSMCs.

KEYWORDS Oxygen radicals; NADPH oxidase; Signal transduction; Smooth muscle

Time for primary review 20 days


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