Skip Navigation

Cardiovascular Research 2006 70(2):391-398; doi:10.1016/j.cardiores.2005.07.005
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Monnet, X.
Right arrow Articles by Berdeaux, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Monnet, X.
Right arrow Articles by Berdeaux, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2006, European Society of Cardiology

Phenotypic adaptation of the late preconditioned heart: Myocardial oxygen consumption is reduced

Xavier Monneta,b,c, Bijan Ghaleha,b,c,d, Laurence Lucatsa,b,c, Patrice Colina,b,c, Roland Zinia,b,c, Luc Hittingera,b,c,d and Alain Berdeauxa,b,c,d,*

aINSERM U660, Créteil, F-94010, France
bEcole Nationale Vétérinaire d'Alfort, Maisons-Alfort, F-94700, France
cLaboratoire de Pharmacologie, Faculté de Médecine de Créteil, Université Paris XII, Créteil, F-94000, France
dFédération de Cardiologie, Hôpital Henri Mondor, Créteil, France

* Corresponding author. Laboratoire de Pharmacologie, INSERM U660, Faculté de Médecine de Créteil, 8, rue du Général Sarrail, 94010 Creteil Cedex, France. Tel.: +33 1 49 81 36 51; fax: +33 1 49 98 17 77. Email address: berdeaux{at}im3.inserm.fr

Objectives Although the signalling pathways of late preconditioning have been extensively investigated, its consequence for myocardial metabolism remains unknown. Thus, myocardial oxygen consumption (MVO2) was evaluated before and under late preconditioning.

Methods In 7 chronically instrumented dogs, we measured MVO2 in vivo at baseline and during inotropic stimulation with dobutamine (10 and 20 µg/kg/min, i.v.) before (Day 0) and 24 h after (Day 1) a 10-min circumflex coronary artery occlusion.

Results At Day 0, dobutamine dose-dependently increased the triple product (heart rate x left ventricular systolic pressure x left ventricular maximum dP/dt), MVO2, coronary blood flow, and coronary sinus pO2. At Day 1, the triple product was similar at baseline and at each dose of dobutamine but MVO2 was significantly blunted as compared to Day 0 (– 15±4%, – 22±3% and – 19±4% at baseline, dobutamine 10 and 20 µg/kg/min, respectively). Importantly, the relationship between MVO2 and triple product was significantly rightward shifted with late preconditioning, i.e., MVO2 was reduced for any level of triple product. At Day 1, the relationship between coronary blood flow and MVO2 was not altered as compared to Day 0 but coronary sinus pO2 was significantly increased vs. Day 0 for any level of coronary blood flow, suggesting that late preconditioning exerted no vasomotor effect but rather changed myocardial oxygen handling. These effects were abolished by administration of S-methyl-isothiourea (1.5 mg/kg, i.v.), a iNOS inhibitor.

Conclusion This study demonstrates that ischemic late preconditioning is characterized by a major reduction in MVO2, both at baseline and under inotropic stimulation. NO from iNOS contributes to this modification of metabolic phenotype.

KEYWORDS Oxygen consumption; Stunning; Nitric oxide; Preconditioning

Time for primary review 20 days


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Nutr.Home page
G. G. Abdukeyum, A. J. Owen, and P. L. McLennan
Dietary (n-3) Long-Chain Polyunsaturated Fatty Acids Inhibit Ischemia and Reperfusion Arrhythmias and Infarction in Rat Heart Not Enhanced by Ischemic Preconditioning
J. Nutr., October 1, 2008; 138(10): 1902 - 1909.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Galkin and S. Moncada
S-Nitrosation of Mitochondrial Complex I Depends on Its Structural Conformation
J. Biol. Chem., December 28, 2007; 282(52): 37448 - 37453.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
G. C. Brown and V. Borutaite
Nitric oxide and mitochondrial respiration in the heart
Cardiovasc Res, July 15, 2007; 75(2): 283 - 290.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
L. Lucats, L. Vinet, A. Bize, X. Monnet, D. Morin, J. B. Su, P. Rouet-Benzineb, O. Cazorla, J.-J. Mercadier, L. Hittinger, et al.
The inotropic adaptation during late preconditioning against myocardial stunning is associated with an increase in FKBP12.6
Cardiovasc Res, February 1, 2007; 73(3): 560 - 567.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
X. Monnet, L. Lucats, P. Colin, G. Derumeaux, J.-L. Dubois-Rande, L. Hittinger, B. Ghaleh, and A. Berdeaux
Reduction in postsystolic wall thickening during late preconditioning
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H158 - H164.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D. Garcia-Dorado, J. Vinten-Johansen, and H. M. Piper
Bringing preconditioning and postconditioning into focus
Cardiovasc Res, May 1, 2006; 70(2): 167 - 169.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.